 Jack WhitehallRex (voice) | Rex (voice) |
 Ray WinstoneTyson (voice) | Tyson (voice) |
 Sheridan SmithWanda (voice) | Wanda (voice) |
 Matt LucasCharlie (voice) | Charlie (voice) |
 Tom CourtenayThe Duke of Edinburgh (voice) | The Duke of Edinburgh (voice) |
 Julie WaltersThe Queen (voice) | The Queen (voice) |
 Jon CulshawTrump / Bernard St Bernard (voice) | Trump / Bernard St Bernard (voice) |
 Debra StephensonMelania / Lady Margaret (voice) | Melania / Lady Margaret (voice) |
 Sarah HadlandMitzi / Vet (voice) | Mitzi / Vet (voice) |
 Colin McFarlaneChief / Nelson (voice) | Chief / Nelson (voice) |
 Nina WadiaPatmore / Mrs Kapoor (voice) | Patmore / Mrs Kapoor (voice) |
 Iain McKeeJack (voice) | Jack (voice) |
 Kulvinder GhirSanjay / Guards / Other Dogs (voice) | Sanjay / Guards / Other Dogs (voice) |
 Rasmus HardikerGinger / Boxer / Chihuahua / Young Rex (voice) | Ginger / Boxer / Chihuahua / Young Rex (voice) |
 Steven KynmanPolux / Al Sation (voice) | Polux / Al Sation (voice) |
| TTwinkle JaiswalLittle Girl (voice) | Little Girl (voice) |
| LLeo BarakatRex (voice) | Rex (voice) |
 Jo WyattWanda (voice) | Wanda (voice) |
| RRusty ShacklefordJack (voice) | Jack (voice) |
| JJane AlanQueen (voice) | Queen (voice) |
 Dino AndradeCharlie / Polux / Walla Group (voice) | Charlie / Polux / Walla Group (voice) |
 Joey CamenTyson / Chihuahua / Al / Sanjay (voice) | Tyson / Chihuahua / Al / Sanjay (voice) |
 Kirk ThorntonTrump (voice) | Trump (voice) |
| MMadison BrownMitzi (voice) | Mitzi (voice) |
 Rick ZieffChief (voice) | Chief (voice) |
| JJamie Arlen ScottBernard / Castor (voice) | Bernard / Castor (voice) |
| MMillie MupMelania / Asian Mom (voice) | Melania / Asian Mom (voice) |
 Lani MinellaGinger / Walla Group (voice) | Ginger / Walla Group (voice) |
| DDavid A. AlanoGuard 1 (voice) | Guard 1 (voice) |
 Daniel WolfeGuard 2 (voice) | Guard 2 (voice) |
