The ups and downs of Blow’s life, championing unknown and marginalised fashion figures like Alexander McQueen, Philip Treacy, and Sophie Dahl, whom she catapulted to success while struggling with undiagnosed bipolar disorder.
| Actor | Role |
|---|---|
 Andrea RiseboroughIsabella Blow | Isabella Blow |
 Richard E. GrantEvelyn Delves Broughton | Evelyn Delves Broughton |
 Fionn O'SheaPhilip Treacy | Philip Treacy |
 Joe ColeAlexander McQueen | Alexander McQueen |
 Dane DeHaanDetmar Blow | Detmar Blow |
 Emily BeechamLucy Birley | Lucy Birley |
 Stacy MartinDaphne Guinness | Daphne Guinness |
 Ncuti GatwaMichael Roberts | Michael Roberts |
 Miranda RichardsonHelen Delves Broughton | Helen Delves Broughton |
 Michelle DockeryAlexandra Shulman | Alexandra Shulman |
 Sebastian de SouzaStefan Bartlett | Stefan Bartlett |
 Vincent PerezBernard Arnault | Bernard Arnault |