The archangel Gabriel returns to try to destroy the human race he despises so much, with the help of a suicidal teen and the opposition of the angel Danyael.
| Actor | Role |
|---|---|
 Christopher WalkenGabriel | Gabriel |
 Russell WongDanyael | Danyael |
 Jennifer BealsValerie Rosales | Valerie Rosales |
 Brittany MurphyIzzy | Izzy |
 Eric RobertsMichael | Michael |
 Glenn DanzigSamayel | Samayel |
 Steve HytnerJoseph | Joseph |
 Bruce AbbottThomas Daggett | Thomas Daggett |
 William PraelRafayel | Rafayel |
 Renée VictorNana | Nana |
 Elizabeth DennehyKathy Kimball | Kathy Kimball |
 J.G. HertzlerFather William | Father William |
 Ethan EmbryYoung Coroner | Young Coroner |
 Nicki MicheauxDetective Kreibel | Detective Kreibel |
 Tom TowlesDetective Waltrip | Detective Waltrip |
 Danny StrongJulian | Julian |
| DDavid LeaHagil | Hagil |
| JJenna RoseJamie | Jamie |
| SStephen EarnhartEMT | EMT |
 David KavinMarvin | Marvin |
 Kathryn MorrisAnxious Mother | Anxious Mother |
| JJake EberleOrderly #1 | Orderly #1 |
| JJim KriegOrderly #2 | Orderly #2 |
| JJim WhiteMorgue Orderly | Morgue Orderly |
| SStephen RamseyCop | Cop |
| GGary PaulPoliceman | Policeman |
| MMichael JimenezMan in Donut Shop | Man in Donut Shop |
| GGil ZunigaMonk | Monk |
| AAlma CollinsWoman | Woman |
| LLeonard O. TurnerBoyfriend | Boyfriend |