The Prairie is set at the time of the Louisiana Purchase. Hoping to find their destiny in the new territory, the Bush Family heads southward in a covered wagon. Sharing the family's numerous dangers and hardships are Ellen Wade (Lenore Aubert), sole survivor of an Indian attack, and army mapmaker Paul Hover (Alan Baxter). Cousins Abiram (Russ Vincent) and Asa (Jack Mitchum) duke it out over Ellen's affections
| Actor | Role |
|---|---|
 Lenore AubertEllen Wade | Ellen Wade |
 Alan BaxterPaul Hover | Paul Hover |
 Russ VincentAbiram White | Abiram White |
 John MitchumAsa Bush | Asa Bush |
 Charles EvansIshmael Bush | Ishmael Bush |
 Edna HollandEsther Bush | Esther Bush |
 Chief ThundercloudEagle Feather | Eagle Feather |
| FFred CobyAbner Bush | Abner Bush |
 William MurphyJess Bush | Jess Bush |
| DDavid GerberGabe Bush | Gabe Bush |
| DDon LynchEnoch Bush | Enoch Bush |
 George MorrellLuke | Luke |
 Chief YowlachieMatoreeh | Matoreeh |
 Jay SilverheelsRunning Deer | Running Deer |
| KKara Beth TaylorAnne Morris | Anne Morris |
| FFrank HemingwayNarrator | Narrator |