The Powerpuff Girls Rule!!!
23m·Animation, Action, TV Movie·
The Powerpuff Girls face their greatest challenge in this 10th anniversary special episode. There exists a Key to the World, which is handed from city to city on an annual basis. Whoever possesses the key rules over the entire world. When the key is delivered to Townsville, every villain in Townsville attempts to retrieve it. When the girls procure it for themselves, they quickly get sucked into a power struggle, fighting the villains and themselves over who gets to rule the world.
| Actor | Role |
|---|---|
 Cathy CavadiniBlossom (voice) | Blossom (voice) |
 Tara StrongBubbles / Alarm System (voice) | Bubbles / Alarm System (voice) |
 E. G. DailyButtercup (voice) | Buttercup (voice) |
 Tom KennyNarrator / Mayor / Dove (voice) | Narrator / Mayor / Dove (voice) |
 Tom KaneProfessor / Him / Talking Dog (voice) | Professor / Him / Talking Dog (voice) |
 Roger L. JacksonMojo Jojo (voice) | Mojo Jojo (voice) |
 Jennifer MartinMs. Bellum (voice) | Ms. Bellum (voice) |
 Kevin Michael RichardsonFish Balloon (voice) | Fish Balloon (voice) |
 Jeff BennettAce / Prisoner / Concerned Citizen (voice) | Ace / Prisoner / Concerned Citizen (voice) |
 Jim CummingsFuzzy Lumpkins (voice) | Fuzzy Lumpkins (voice) |
 Jennifer HalePrincess (voice) | Princess (voice) |