 Russell CroweFather Gabriele Amorth | Father Gabriele Amorth |
 Daniel ZovattoFather Esquibel | Father Esquibel |
 Alex EssoeJulia | Julia |
 Peter DeSouza-FeighoneyHenry | Henry |
 Ralph InesonAsmodeus (voice) | Asmodeus (voice) |
 Laurel MarsdenAmy | Amy |
 Franco NeroThe Pope | The Pope |
 Ryan O'GradyCardinal Sullivan | Cardinal Sullivan |
 Bianca BardoeRosaria | Rosaria |
 Carrie MunroAdella | Adella |
 Cornell JohnBishop Lumumba | Bishop Lumumba |
 Santi BayónRoberto Vasquez IV (Henry's Dad) | Roberto Vasquez IV (Henry's Dad) |
 Paloma BloydInterpreter | Interpreter |
 Alessandro GruttadauriaFather Gianni | Father Gianni |
 River HawkinsEnzo / Halphas | Enzo / Halphas |
 Jordi ColletCarlos | Carlos |
 Marc VelascoWorker 1 | Worker 1 |
 Edward Harper-JonesYoung Amorth | Young Amorth |
 Matthew SimCardinal Abato | Cardinal Abato |
 Victor SoléSpanish Doctor | Spanish Doctor |
 Tom BoningtonVatican Doctor | Vatican Doctor |
 Andrea DugoniDrunken Farmer | Drunken Farmer |
 Ed WhiteNazi Soldier | Nazi Soldier |
 Laila BarwickDaughter (Farmhouse) | Daughter (Farmhouse) |
 Gennaro DianaItalian Priest | Italian Priest |
 Pablo RaybouldBishop Barbuto | Bishop Barbuto |
 Derek CarrollDoctor (uncredited) | Doctor (uncredited) |
| EElla CannonPartisan #2 (uncredited) | Partisan #2 (uncredited) |
| AAmey De SouzaVillager (uncredited) | Villager (uncredited) |
 Neha DubeyYoung Nun (uncredited) | Young Nun (uncredited) |
