 Don MurrayWild Bill Hickok | Wild Bill Hickok |
 Guy StockwellBuffalo Bill Cody | Buffalo Bill Cody |
 Abby DaltonCalamity Jane | Calamity Jane |
 Bradford DillmanLt. Stiles | Lt. Stiles |
 Henry SilvaCrazy Knife | Crazy Knife |
 Simon OaklandChief Black Kettle | Chief Black Kettle |
 Leslie NielsenCol. George Armstrong Custer | Col. George Armstrong Custer |
 Edward BinnsLattimer | Lattimer |
 Michael EvansEstrick | Estrick |
 Percy RodriguezBrother John | Brother John |
 Terry WilsonSgt. Womack | Sgt. Womack |
 Walter BurkeAbe Ireland | Abe Ireland |
 Emily BanksLouisa Cody | Louisa Cody |
| RRichard AldenOrderly (uncredited) | Orderly (uncredited) |
 John BurnsideTownsman (uncredited) | Townsman (uncredited) |
| AAlbert CavensClerk (uncredited) | Clerk (uncredited) |
| BBud CokesTownsman (uncredited) | Townsman (uncredited) |
| NNeil CollinsBartender (uncredited) | Bartender (uncredited) |
 Francis De SalesJohansen (uncredited) | Johansen (uncredited) |
| JJerado DecordovierIndian (uncredited) | Indian (uncredited) |
| BBob FolkersonPoker Player (uncredited) | Poker Player (uncredited) |
| TTex HoldenTownsman (uncredited) | Townsman (uncredited) |
 Jimmie HoranTownsman (uncredited) | Townsman (uncredited) |
 Roy JensonRenegade Soldier (uncredited) | Renegade Soldier (uncredited) |
| TTex LambertTownsman (uncredited) | Townsman (uncredited) |
 David MacklinTrooper (uncredited) | Trooper (uncredited) |
 John MitchumTownsman (uncredited) | Townsman (uncredited) |
| EEdwin RochelleDoctor (uncredited) | Doctor (uncredited) |
| RRube SchafferTownsman (uncredited) | Townsman (uncredited) |
| VVincent St. CyrSioux Chief (uncredited) | Sioux Chief (uncredited) |
