In London, barrister Anthony Keane takes the case of Maddalena Paradine, a beautiful woman accused of poisoning her blind husband. Though happily married, Keane becomes infatuated with his enigmatic client and convinced of her innocence. His obsession clouds his judgment as he builds a defense implicating her servant, André Latour—an act that leads to devastating consequences both in court and at home.
| Actor | Role |
|---|---|
 Gregory PeckAnthony Keane | Anthony Keane |
 Ann ToddGay Keane | Gay Keane |
 Alida ValliMrs. Paradine | Mrs. Paradine |
 Charles LaughtonJudge Lord Thomas Horfield | Judge Lord Thomas Horfield |
 Charles CoburnSir Simon Flaquer | Sir Simon Flaquer |
 Ethel BarrymoreLady Sophie Horfield | Lady Sophie Horfield |
 Louis JourdanAndre Latour | Andre Latour |
 Leo G. CarrollSir Joseph | Sir Joseph |
 Joan TetzelJudy Flaquer | Judy Flaquer |
 Isobel ElsomInnkeeper | Innkeeper |
 Harry 'Snub' PollardCabby (uncredited) | Cabby (uncredited) |
 Kenner G. KempCourtroom Spectator (uncredited) | Courtroom Spectator (uncredited) |
 Colin KennyJuror (uncredited) | Juror (uncredited) |
| BBert StevensBarrister in Courtroom (uncredited) | Barrister in Courtroom (uncredited) |
 Arthur ToveyCourtroom Spectator (uncredited) | Courtroom Spectator (uncredited) |
| SSam HarrisCourtroom Spectator (uncredited) | Courtroom Spectator (uncredited) |