Rance Roden plans to kill off all the buffalo and thus cause the Indians to riot. After they destroy the US Cavalry, Rance and his gang will take over the West. Meanwhile, a Boston magazine gets wind of the buffalo slaughter and sends editor Kenneth Cabot and his associates to Casper, Wyoming to investigate.
| Actor | Role |
|---|---|
 Moe HowardMoe | Moe |
 Larry FineLarry | Larry |
 Joe DeRitaCurly-Joe | Curly-Joe |
 Adam WestKenneth Cabot | Kenneth Cabot |
 Nancy KovackAnnie Oakley | Annie Oakley |
 Mort MillsTrigger Mortis | Trigger Mortis |
| DDon LamondRance Roden | Rance Roden |
 Rex HolmanSunstroke Kid | Sunstroke Kid |
 Emil SitkaMr. Abernathy / Witch doctor / Cavalry colonel | Mr. Abernathy / Witch doctor / Cavalry colonel |
 Henry GibsonCharlie Horse | Charlie Horse |
 Murray AlperChief Crazy Horse | Chief Crazy Horse |
| TTiny BrauerBartender | Bartender |
| SSidney MarionHammond | Hammond |
| JJeffrey ScottKid | Kid |
| MMarilyn FoxGirl #1 | Girl #1 |
 Sally StarrBelle Starr | Belle Starr |
| WWayne MackJesse James | Jesse James |