 Fred MacMurrayNeal Harris | Neal Harris |
 William BishopCaptain George Wayne | Captain George Wayne |
 Nina ShipmanPrudence Cooper | Prudence Cooper |
 Gloria TalbottShona Hastings | Shona Hastings |
 Henry HullGeorge Seton | George Seton |
 John CarradineZachariah Garrison | Zachariah Garrison |
 John DierkesGabe Hastings | Gabe Hastings |
| RRoxene WellsFlossie Shoemaker | Flossie Shoemaker |
 Elizabeth PattersonMaria Cooper | Maria Cooper |
| GGene N. FowlerRichard Cooper | Richard Cooper |
 James BellJeremiah Cooper | Jeremiah Cooper |
| JJohn SlosserJohnny | Johnny |
 Ralph SanfordJohn Decker | John Decker |
| SSherry SpaldingLucy | Lucy |
| TTex TerryBrizzard | Brizzard |
 Ollie O'TooleJames Gordon Bennett | James Gordon Bennett |
| AArvo OjalaEllis | Ellis |
| EEd WrightJesse | Jesse |
 Addison RichardsPresident James Polk (uncredited) | President James Polk (uncredited) |
 Lumsden HareSir Richard Wallingham (uncredited) | Sir Richard Wallingham (uncredited) |
 Oscar Beregi Jr.Ralph Clayman (uncredited) | Ralph Clayman (uncredited) |
 Chet BrandenburgWagon Train Member at Fort (uncredited) | Wagon Train Member at Fort (uncredited) |
| RRaven Grey EagleIndian (uncredited) | Indian (uncredited) |
| JJim WhitecloudIndian (uncredited) | Indian (uncredited) |
 Harry 'Snub' PollardTownsman (uncredited) | Townsman (uncredited) |
| AAl HaskellTownsman (uncredited) | Townsman (uncredited) |
 Jimmy DimeTownsman (uncredited) | Townsman (uncredited) |
| SSally YarnellTownswoman (uncredited) | Townswoman (uncredited) |
