 Dennis WeaverDr. Samuel A. Mudd | Dr. Samuel A. Mudd |
 Susan SullivanFrances Mudd | Frances Mudd |
 Richard DysartEdwin Stanton | Edwin Stanton |
 Michael McGuireCapt. Murdock | Capt. Murdock |
 Nigel DavenportColonel George Grenfell | Colonel George Grenfell |
 Arthur HillGeneral Thomas Ewing | General Thomas Ewing |
 Larry LarsonRiggins Thorpe | Riggins Thorpe |
 Mary Nell SantacroceEllen Stanton | Ellen Stanton |
| CClarence ThomasNathaniel | Nathaniel |
| TTeddy MilfordAndrew Mudd at Age 6 | Andrew Mudd at Age 6 |
| AAngela TullySissy Mudd at Age 4 | Sissy Mudd at Age 4 |
| RRyan GradyThomas Mudd at Age 3 | Thomas Mudd at Age 3 |
| BBill GribbleTyler / John Wilkes Booth | Tyler / John Wilkes Booth |
 Luke HalpinTyson / David Herrold | Tyson / David Herrold |
 Terry BeaverUnion Sergeant | Union Sergeant |
| SSean Ahern1st Union Soldier | 1st Union Soldier |
| RRoy TatumLt. Lovett | Lt. Lovett |
| DDon KovacsOfficer Lloyd | Officer Lloyd |
 Lawrence MontaigneJudge Holt | Judge Holt |
 Harold BergmanUndersecretary | Undersecretary |
| FFred CovingtonAttorney Lake | Attorney Lake |
 Joe DorseyGen. Edward Trafe | Gen. Edward Trafe |
| JJim PeckGen. Harris | Gen. Harris |
| GGreg OliverLouis Weichmann | Louis Weichmann |
 Bill EudalyDaniel Thomas | Daniel Thomas |
| DDon DevendorfGeorge Mudd | George Mudd |
| TTony KishWilliam Watson | William Watson |
| WWallace WilkinsonD.C. Prison Guard | D.C. Prison Guard |
| AAnthony EdenfieldEscaped Prisoner | Escaped Prisoner |
| JJere Beery3rd Guard | 3rd Guard |