 Bobby HoseaO.J. Simpson | O.J. Simpson |
 Jessica TuckNicole Brown Simpson | Nicole Brown Simpson |
 David RobersonA.C. Cowlings | A.C. Cowlings |
 James HandyDetective Vannatter | Detective Vannatter |
 Kimberly RussellMarguerite | Marguerite |
 Harvey JasonHoward Weitzman | Howard Weitzman |
 Bruce WeitzRobert Shapiro | Robert Shapiro |
| MMariann AaldaO.J.'s Mom Eunice | O.J.'s Mom Eunice |
 Steve AkahoshiTV Detective No. 2 | TV Detective No. 2 |
| EEliana AlexanderYoung Woman | Young Woman |
| JJacques Apollo BoltonTeammate | Teammate |
 John CannFreeway Chris | Freeway Chris |
 Darwyn CarsonWoman Prosecutor | Woman Prosecutor |
| MMartin CassidyTV Detective | TV Detective |
 Gary Carlos CervantesPolice Spokesman | Police Spokesman |
| NNoel ConlonNicole's Father | Nicole's Father |
 Pamela DunlapTherapist | Therapist |
 Richard FancyEd Ledbetter | Ed Ledbetter |
| LLeo GreeneAnchorman No. 2 | Anchorman No. 2 |
| RRandy HamiltonActing Doctor on TV | Acting Doctor on TV |
| JJonathan R. HoogJustin | Justin |
 Terrence HowardYoung A.C. | Young A.C. |
| TTimothy O'Neale HutchinsonO.J. Officer No. 1 | O.J. Officer No. 1 |
| HHelaine LembeckJournalist / Interviewer | Journalist / Interviewer |
 Jarrett LennonKevin | Kevin |
 James LesureA.C.'s Cop | A.C.'s Cop |
| GGary LindseyAnchorman No. 1 | Anchorman No. 1 |
 Barry LivingstonDr. Berney | Dr. Berney |
| HHenry MarshallDan | Dan |
 Toy NewkirkYoung Marguerite | Young Marguerite |