 Will ArnettSurly (voice) | Surly (voice) |
 Maya RudolphPrecious (voice) | Precious (voice) |
 Bobby CannavaleFrankie (voice) | Frankie (voice) |
 Bobby MoynihanMayor Muldoon (voice) | Mayor Muldoon (voice) |
 Isabela MercedHeather (voice) | Heather (voice) |
 Peter StormareGunther (voice) | Gunther (voice) |
 Gabriel IglesiasJimmy (voice) | Jimmy (voice) |
 Jeff DunhamMole (voice) | Mole (voice) |
 Sebastian ManiscalcoJohnny (voice) | Johnny (voice) |
 Kari WahlgrenJamie / Additional Voices (voice) | Jamie / Additional Voices (voice) |
 Jackie ChanMr. Feng (voice) | Mr. Feng (voice) |
 Katherine HeiglAndie (voice) | Andie (voice) |
 Julie LemieuxLil' Chip / Additional Voices (voice) | Lil' Chip / Additional Voices (voice) |
 Dwayne HillPolice Officer / Additional Voices (voice) | Police Officer / Additional Voices (voice) |
 Josh Robert ThompsonConstruction Foreman / Additional Voices (voice) | Construction Foreman / Additional Voices (voice) |
 Rob TinklerRedline (voice) | Redline (voice) |
 Jess HarnellAnimal Control Guy 1 / Additional Voices (voice) | Animal Control Guy 1 / Additional Voices (voice) |
 Fred TatascioreAnimal Control Guy 2 (voice) | Animal Control Guy 2 (voice) |
 Andrew OrtenbergAnimal Control Guy 3 (voice) | Animal Control Guy 3 (voice) |
 Greg ChunMouse Henchman (voice) | Mouse Henchman (voice) |
 Dave FennoyMouse Henchman 2 / Additional Voices (voice) | Mouse Henchman 2 / Additional Voices (voice) |
 Laraine NewmanDaredevil Chipmunk (voice) | Daredevil Chipmunk (voice) |
 Justin FelbingerYoung Surly (voice) | Young Surly (voice) |
 Cal BrunkerCharming Chipmunk (voice) | Charming Chipmunk (voice) |
 Bob BarlenHandsome Mouse (voice) | Handsome Mouse (voice) |
| EEmma DaleAdditional Voices (voice) | Additional Voices (voice) |
 Lukas EngelAdditional Voices (voice) | Additional Voices (voice) |
| JJamie DennisAdditional Voices (voice) | Additional Voices (voice) |
 Jonathan DixonAdditional Voices (voice) | Additional Voices (voice) |
