 Claude RainsJohn Jasper | John Jasper |
 Douglass MontgomeryNeville Landless | Neville Landless |
 Heather AngelRosa Bud | Rosa Bud |
 Valerie HobsonHelena Landless | Helena Landless |
 David MannersEdwin Drood | Edwin Drood |
 Francis L. SullivanRev. Mr. Crisparkle | Rev. Mr. Crisparkle |
 Zeffie TilburyThe Opium Woman | The Opium Woman |
 Ethel GriffiesMiss Twinkleton | Miss Twinkleton |
 E. E. CliveSapsea | Sapsea |
 Walter KingsfordGrewgious | Grewgious |
 Forrester HarveyDurdles | Durdles |
| VVeda BucklandMrs. Tope | Mrs. Tope |
| EElsa BuchananMrs. Tisher | Mrs. Tisher |
 George ErnestDeputy | Deputy |
 J.M. KerriganChief Verger Tope | Chief Verger Tope |
 Bunny BeattySchoolgirl (uncredited) | Schoolgirl (uncredited) |
 May BeattySchool Cook (uncredited) | School Cook (uncredited) |
| EEvelyn BeresfordOld Maid (uncredited) | Old Maid (uncredited) |
 Walter BrennanMilkman (uncredited) | Milkman (uncredited) |
| RRosita ButlerSchoolgirl (uncredited) | Schoolgirl (uncredited) |
 Louise CarterMrs. Crisparkle (uncredited) | Mrs. Crisparkle (uncredited) |
| EEdward CooperDean (uncredited) | Dean (uncredited) |
 Harry CordingTurk, an Opium Addict (uncredited) | Turk, an Opium Addict (uncredited) |
 D'Arcy CorriganOpium Addict (uncredited) | Opium Addict (uncredited) |
 Anne DarlingSchoolgirl (uncredited) | Schoolgirl (uncredited) |
 Gordon DouglasCoroner (uncredited) | Coroner (uncredited) |
 Effie EllslerTownswoman (uncredited) | Townswoman (uncredited) |
 Will GeerVillage Lamplighter (uncredited) | Village Lamplighter (uncredited) |
| HHelena GrantMaid (uncredited) | Maid (uncredited) |
| AAnne HarrisonSchoolgirl (uncredited) | Schoolgirl (uncredited) |
