A Chinese doctor vows revenge against the allied troops who killed his wife and child during the Boxer Rebellion.
| Actor | Role |
|---|---|
 Warner OlandDr. Fu Manchu | Dr. Fu Manchu |
 Neil HamiltonDr. Jack Petrie | Dr. Jack Petrie |
 Jean ArthurLia Eltham | Lia Eltham |
 O. P. HeggieInspector Nayland Smith | Inspector Nayland Smith |
 William AustinSylvester Wadsworth | Sylvester Wadsworth |
 Claude KingSir John Petrie | Sir John Petrie |
 Charles A. StevensonGeneral Petrie | General Petrie |
 Evelyn SelbieFai Lu | Fai Lu |
 Noble JohnsonLi Po | Li Po |
 Laska WinterFu Mela | Fu Mela |
 Wong ChungChinese Official (uncredited) | Chinese Official (uncredited) |
 Lawford DavidsonNot listed | Not listed |
| CChappell DossettNot listed | Not listed |
 Charles GiblynNot listed | Not listed |
| DDonald MacKenzieNot listed | Not listed |
 Tully MarshallNot listed | Not listed |
| EEvelyn MillsNot listed | Not listed |
| WWilliam J. O'BrienNot listed | Not listed |
 Charles StevensNot listed | Not listed |