 Boris KarloffDr. Fu Manchu | Dr. Fu Manchu |
 Lewis StoneNyland Smith | Nyland Smith |
 Karen MorleySheila Barton | Sheila Barton |
 Charles StarrettTerence Granville | Terence Granville |
 Myrna LoyFah Lo See | Fah Lo See |
 Jean HersholtVon Berg | Von Berg |
 Lawrence GrantSir Lionel Barton | Sir Lionel Barton |
 David TorrenceMcLeod | McLeod |
 C. Montague ShawCurator Dr. Fairgyle - British Museum Official (uncredited) | Curator Dr. Fairgyle - British Museum Official (uncredited) |
 Steve ClementeKnife Thrower (uncredited) | Knife Thrower (uncredited) |
| AAllen JungCoolie (uncredited) | Coolie (uncredited) |
 Chris-Pin MartinPotentate (uncredited) | Potentate (uncredited) |
 Edward Peil Sr.Coolie Spy (uncredited) | Coolie Spy (uncredited) |
 Willie FungShip's Steward (uncredited) | Ship's Steward (uncredited) |
 E. Alyn WarrenGoy Lo Sung - Fu Manchu Messenger (uncredited) | Goy Lo Sung - Fu Manchu Messenger (uncredited) |
 Olive YoungCantina singer (uncredited) | Cantina singer (uncredited) |
 Everett BrownSlave (uncredited) | Slave (uncredited) |
 Clinton RosemondSlave (uncredited) | Slave (uncredited) |
