Lecturer and broadcaster Sheridan Whiteside has been invited to dinner at the home of a pompous small-town bigwig. But he stays rather longer than anyone expects.
| Actor | Role |
|---|---|
 Orson WellesSheridan Whiteside | Sheridan Whiteside |
 Lee RemickMaggie Cutler | Maggie Cutler |
 Joan CollinsLorraine Sheldon | Lorraine Sheldon |
 Don KnottsDr. Bradley | Dr. Bradley |
 Edward AndrewsErnest W. Stanley | Ernest W. Stanley |
 Marty FeldmanBanjo | Banjo |
 Michael GoughBeverly Carlton | Beverly Carlton |
 Kim BradenJune Stanley | June Stanley |
| HHal GaliliDelivery Man | Delivery Man |
 Peter HaskellBert Jefferson | Bert Jefferson |
 Tutte LemkowZoltan | Zoltan |
 Al ManciniWestcott | Westcott |
| MMarcella MarkhamMrs. Stanley | Mrs. Stanley |
 Betty McDowallMrs. McCutcheon | Mrs. McCutcheon |
 George PravdaProf. Metz | Prof. Metz |
 Anita Sharp-BolsterHarriet Stanley | Harriet Stanley |
| FFrank SinguineauJohn | John |
| EElisabeth WelchSarah | Sarah |
 Mary WickesNurse Preen | Nurse Preen |