Humorist Roy Blount Jr. takes viewers on a journey down the Mississippi River, showcasing everything from areas with spectacularly beautiful scenery to ugly and dangerously polluted stretches bordered by industrial development.
| Actor | Role |
|---|---|
| RRoy Blount Jr.Himself | Himself |
 Garrison KeillorHimself | Himself |
 Winona LaDukeHerself | Herself |
| JJames Michael WhiteHimself | Himself |