 Joseph CottenEugene Morgan | Eugene Morgan |
 Dolores CostelloIsabel Amberson Minafer | Isabel Amberson Minafer |
 Anne BaxterLucy Morgan | Lucy Morgan |
 Tim HoltGeorge Minafer | George Minafer |
 Agnes MooreheadFanny Minafer | Fanny Minafer |
 Ray CollinsJack Amberson | Jack Amberson |
 Erskine SanfordRoger Bronson | Roger Bronson |
 Richard BennettMajor Amberson | Major Amberson |
 Orson WellesNarrator (voice) | Narrator (voice) |
 Edwin AugustCitizen (uncredited) | Citizen (uncredited) |
 Georgia BackusMatron (uncredited) | Matron (uncredited) |
| HHarry A. BaileyCitizen (uncredited) | Citizen (uncredited) |
| OOlive BallMary (Maid) (uncredited) | Mary (Maid) (uncredited) |
| JJack BaxleyReverend Smith (uncredited) | Reverend Smith (uncredited) |
| WWilliam BleesYoung Man at Accident (uncredited) | Young Man at Accident (uncredited) |
| LLyle ClementCitizen (uncredited) | Citizen (uncredited) |
| BBobby CooperGeorge Minafer as a Boy (uncredited) | George Minafer as a Boy (uncredited) |
 Don DillawayWilbur Minafer (uncredited) | Wilbur Minafer (uncredited) |
| HHeenan ElliottWorkman (uncredited) | Workman (uncredited) |
 John ElliottGuest (uncredited) | Guest (uncredited) |
 William ElmerServant (uncredited) | Servant (uncredited) |
| JJames FawcettCitizen (uncredited) | Citizen (uncredited) |
| MMel FordFred Kinney (uncredited) | Fred Kinney (uncredited) |
 Nancy GatesGirl (uncredited) | Girl (uncredited) |
| NNina GuilbertGuest (uncredited) | Guest (uncredited) |
 Maynard HolmesCitizen (uncredited) | Citizen (uncredited) |
| EEdward HowardChauffeur (uncredited) | Chauffeur (uncredited) |
 Harry HumphreyCitizen (uncredited) | Citizen (uncredited) |
| EElmer JeromeFuneral Attendee (uncredited) | Funeral Attendee (uncredited) |
| JJ. Louis JohnsonSam (Butler) (uncredited) | Sam (Butler) (uncredited) |
