 Linda DarnellVirginia Clemm | Virginia Clemm |
 Shepperd StrudwickEdgar Allan Poe | Edgar Allan Poe |
 Virginia GilmoreElmira Royster | Elmira Royster |
 Jane DarwellMariah Clemm | Mariah Clemm |
 Mary HowardFrances Allan | Frances Allan |
 Frank ConroyJohn Allan | John Allan |
 Harry MorganEbenezer Burling | Ebenezer Burling |
 Walter KingsfordT.W. White | T.W. White |
 Morris AnkrumMr. Graham | Mr. Graham |
 William BakewellHugh Pleasant | Hugh Pleasant |
 Francis FordTavern Keeper | Tavern Keeper |
 Mae MarshMrs. Phillips (uncredited) | Mrs. Phillips (uncredited) |
 Bert MoorhouseWest Point Board Officer (uncredited) | West Point Board Officer (uncredited) |
 Arthur ShieldsGriswald (uncredited) | Griswald (uncredited) |
| SSkippy WandersPoe, age 3 | Poe, age 3 |
 Freddie MercerPoe, age 12 | Poe, age 12 |
 Erville AldersonBurke | Burke |
 Peggy McIntyreElmira, age 10 | Elmira, age 10 |
 Frank MeltonTurner Dixon | Turner Dixon |
 Morton LowryCharles Dickens | Charles Dickens |
 Gilbert EmeryThomas Jefferson | Thomas Jefferson |
 Edwin StanleyDr. Moran | Dr. Moran |
| HHarry DennyKennedy | Kennedy |
 Hardie AlbrightShelton | Shelton |
 Harry CarterJefferson's Messenger (uncredited) | Jefferson's Messenger (uncredited) |
