A sex therapist goes through puberty after the successful removal of a benign tumor resting against his pituitary gland. He experiences all the changes and effects of puberty over a three-week period.
| Actor | Role |
|---|---|
 Johnny SimmonsDr. Peter Newmans | Dr. Peter Newmans |
 Brittany SnowMichelle | Michelle |
 J.K. SimmonsJames Newmans | James Newmans |
 Jane LynchCaroline | Caroline |
 Maria BelloBrenda Newmans | Brenda Newmans |
 Beck BennettLuke | Luke |
 Kumail NanjianiRich | Rich |
 Paul WesleyCharlie | Charlie |
 Charlotte McKinneyAttractive Woman | Attractive Woman |
 Ken MarinoMr. Hanson | Mr. Hanson |
 Matt JonesMax | Max |
 Illeana DouglasLinda | Linda |
 Laraine NewmanNoema Willcoxen | Noema Willcoxen |
 Brian Doyle-MurrayStagehand | Stagehand |
 Joey GreerDoug | Doug |
 Lenora CrichlowNikki | Nikki |
| VVanessa RaglandJenny | Jenny |
 Bobby FlayHimself | Himself |
 Sam RobardsDr. Lawson | Dr. Lawson |
 Blake CooperJosh | Josh |
 Roxanna DunlopMontana | Montana |
 Lauren ShawRosalyn | Rosalyn |
 Nathan CooperHost | Host |
| TTara GrantTinder Girl #3 | Tinder Girl #3 |