The Last of Mrs. Lincoln depicts the final seventeen years of Mary Todd Lincoln's life, following her husband's assassination.
| Actor | Role |
|---|---|
 Julie HarrisMary Todd Lincoln | Mary Todd Lincoln |
 Michael CristoferRobert Lincoln | Robert Lincoln |
 Robby BensonTad Lincoln | Tad Lincoln |
 Patrick DuffyLewis Baker | Lewis Baker |
 Linda KelseyMary Harlan | Mary Harlan |
 Priscilla MorrillElizabeth Edwards | Elizabeth Edwards |
 Denver PyleSenator Austin | Senator Austin |
 Ford RaineyNinnian Edwards | Ninnian Edwards |
| BBilly SimpsonYoung Tad Lincoln | Young Tad Lincoln |
 Royce WallaceLizzie | Lizzie |
| KKate WilkinsonMrs. McCullough | Mrs. McCullough |
 John FurlongPorter | Porter |
| KKurtis LeeGrandson | Grandson |
 Macon McCalmanAttendant | Attendant |
| JJoe 'Flash' RileyNot listed | Not listed |