 Jon VoightAlfred Kroeber | Alfred Kroeber |
 Graham GreeneIshi | Ishi |
 David Ogden StiersDr. Saxton Pope | Dr. Saxton Pope |
 Jack BlessingTom Waterman | Tom Waterman |
 Anne ArcherHenriette Kroeber | Henriette Kroeber |
 Daniel BenzaliMr. Whitney | Mr. Whitney |
| CChristianne HauberMiss Edna Block | Miss Edna Block |
 Charles MartinetAssistant Museum Director | Assistant Museum Director |
| CCarl D. ParkerSheriff Weber | Sheriff Weber |
 Angela PatonMrs. Gustafson | Mrs. Gustafson |
| BBenne AlderMrs. Whatley | Mrs. Whatley |
| MMarie BainNurse | Nurse |
| LLoryn BarleseIshi's Young Sister | Ishi's Young Sister |
| GGilbert BearIshi's Father | Ishi's Father |
| LLance BradyReporter #4 | Reporter #4 |
| RRoy ConradReporter #2 | Reporter #2 |
| KKevin GoetzMedical Student | Medical Student |
| NNeva HutchinsonMrs. Berney | Mrs. Berney |
| JJohn IckesMuseum Director (as John Z. Ickes) | Museum Director (as John Z. Ickes) |
| TTrudy KinersonIshi's Sister | Ishi's Sister |
| BBeverly LaBeauIshi's Mother | Ishi's Mother |
| SStephen LofaroDoctor | Doctor |
 George MaguireMr. Whatley | Mr. Whatley |
| EEdward MarkmannPhotographer | Photographer |
| WWanda McCaddonWoman with Hat | Woman with Hat |
| SSean David McClellandReporter #3 | Reporter #3 |
 C.W. MorganRudy | Rudy |
 James O'ConnellWester Union Operator | Wester Union Operator |
| JJohn OlsonMuseum Goer | Museum Goer |
| SStephen PocockBob | Bob |
