Miguel, a heroic Spanish doctor, puts himself in harm's way to deliver medical treatment to the victims of military uprisings in Africa.
| Actor | Role |
|---|---|
 Charlize TheronDr. Wren Petersen | Dr. Wren Petersen |
 Javier BardemDr. Miguel Leon | Dr. Miguel Leon |
 Jean RenoDr. Mehmet Love | Dr. Mehmet Love |
 Adèle ExarchopoulosEllen | Ellen |
 Jared HarrisDr. Farber | Dr. Farber |
 Hopper PennBilly Boggs | Billy Boggs |
 Denise NewmanSarie | Sarie |
| MMark De VilliersWren's Father | Wren's Father |
| AAmy Harries-JonesYoung Wren | Young Wren |
| OObed BaloyiAtef | Atef |
 Merritt WeverMarlee | Marlee |
| VVaneshran ArumugamEast Indian UN Staffer | East Indian UN Staffer |
 Tinarie Van Wyk-LootsUN Staffer | UN Staffer |
| SSebelethu BonkoloSam | Sam |
 Sibongile MlamboAssatu | Assatu |
 Bill GerberUN Representative | UN Representative |
 Bronwyn ReedCatholic School Girl | Catholic School Girl |
 Chris GxalabaOom Pieter | Oom Pieter |
 Fiona RamsayBeatrice | Beatrice |
| SSarah MuhohoSierra Leone Villager | Sierra Leone Villager |
 Linda SokhuluTriage Nurse | Triage Nurse |
 Ebby WeyimeNurse | Nurse |
| AAndile Vuyolwethu PakadeYouth Soldier | Youth Soldier |
 Elodie VenecePriya | Priya |
 Oscar BestDr. Brown | Dr. Brown |
 Asante MabuzaMena | Mena |