Dr. Nishiyama has to combat increasingly bizarre events on which seem all too familiar to the French prophet Nostradamus's predictions.
| Actor | Role |
|---|---|
| JJack RylandNarrator | Narrator |
 Riley JacksonSportscaster / Crowd Leader | Sportscaster / Crowd Leader |
 Tetsuro TambaDr. Nishiyama | Dr. Nishiyama |
 Matthew OramDr. Nishiyama (voice) / Botanist (voice) | Dr. Nishiyama (voice) / Botanist (voice) |
 Kaoru YumiMariko Nishiyama | Mariko Nishiyama |
 Linda MassonMariko Nishiyama (voice) | Mariko Nishiyama (voice) |
 Toshio KurosawaAkira Nakagawa | Akira Nakagawa |
 Barry HaighAkira Nakagawa (voice) / Zoologist (voice) | Akira Nakagawa (voice) / Zoologist (voice) |
 Takashi ShimuraHospital Director | Hospital Director |
| TTony MooreHospital Director (voice) | Hospital Director (voice) |
 Akihiko HirataBotanist | Botanist |
 Hiroshi KoizumiZoologist | Zoologist |
 Mizuho SuzukiDirector General of Environment Agency | Director General of Environment Agency |
 Michael RossDirector General of Environment Agency (voice) | Director General of Environment Agency (voice) |
 Carolyn LevineVoice of Nostradamus's Prophecies | Voice of Nostradamus's Prophecies |