When LAPD computer expert Peter Fowler investigates the killing of an old man in Chinatown, he finds the only witness is his dog, Cho Cho. But Fowler soon discovers Cho Cho is the only dog in the world who can speak to humans... not only that, Cho Cho is an expert in martial arts. When they join forces to track down the mastermind behind the death of Cho Cho's master, it leads these unusual partners into uncovering a dangerous conspiracy which puts both of their lives in danger.
| Actor | Role |
|---|---|
 Chevy ChaseCho-Cho (voice) | Cho-Cho (voice) |
 Jon VoightHamilton Cage | Hamilton Cage |
 Simon RexPeter Fowler | Peter Fowler |
 Jaime PresslyAshley Wilkenson | Ashley Wilkenson |
 Pat MoritaChin Li | Chin Li |
 Thomas KretschmannGerber | Gerber |
 Ron LesterEdward Cage | Edward Cage |
| BBonnie PaulMargaret Cage | Margaret Cage |
 Nicollette SheridanWhite Cat (voice) | White Cat (voice) |
 Lori PettyCOLAR (voice) | COLAR (voice) |
 Garry ChalkBrunelli | Brunelli |
 Diego WallraffGonzales | Gonzales |
 Bill CroftLocke | Locke |
| EEd AndersWolfgang | Wolfgang |
 Candus Churchill911 Operator | 911 Operator |
 Dagmar MidcapTV Reporter | TV Reporter |
 Linda PorterSouthern Beauty | Southern Beauty |
 Lauren K. RobekPoodle (voice) | Poodle (voice) |
| MMike CrestejoThug | Thug |
| BBrian TonomuraThug | Thug |
| PPhil ChiuThug | Thug |
 Don LewThug | Thug |
| MMitchell Allen SnaryGuard | Guard |
| BBruce TartagliaGuard | Guard |
| KKevin CarneyGuard | Guard |
| AAlbert MasonGuard | Guard |
 Primo the DogDog (uncredited) | Dog (uncredited) |
 Janyse JaudMary Beth (voice) (uncredited) | Mary Beth (voice) (uncredited) |
| DDeren AbramThug (uncredited) | Thug (uncredited) |