A plane crash surviving attorney stumbles upon a mysterious island and is shocked to discover that a brilliant scientist and his lab assistant have found a way to combine human and animal DNA—with horrific results.
| Actor | Role |
|---|---|
 Marlon BrandoDr. Moreau | Dr. Moreau |
 Val KilmerMontgomery | Montgomery |
 David ThewlisDouglas | Douglas |
 Fairuza BalkAissa | Aissa |
 Ron PerlmanSayer of the Law | Sayer of the Law |
 Marco HofschneiderM'Ling | M'Ling |
 Temuera MorrisonAzazello | Azazello |
 William HootkinsKiril | Kiril |
| DDaniel RigneyHyena-Swine | Hyena-Swine |
| NNelson de la RosaMajai | Majai |
| PPeter ElliottAssassimon | Assassimon |
 Mark DacascosLo-Mai | Lo-Mai |
| MMiguel LópezWaggdi | Waggdi |
 Neil G. YoungBoar Man | Boar Man |
| DDavid HudsonBison Man | Bison Man |
 Clare GrantFox Lady | Fox Lady |
| KKitty SilverSow Lady #1 | Sow Lady #1 |
| FFiona MahlSow Lady #2 | Sow Lady #2 |
| AAgoes Widjaya SoedjarwoCaptain | Captain |
 Ron VreekenSoldier #1 | Soldier #1 |
| LLou HorváthSoldier #2 | Soldier #2 |
 Frank WelkerAssassimon (voice) (uncredited) | Assassimon (voice) (uncredited) |
 Richard StanleyBulldog Man (uncredited) | Bulldog Man (uncredited) |
 Morgan SmallboneDog Man (uncredited) | Dog Man (uncredited) |