The Good Comrades are a collection of varied gentlemen who crave one thing - solitude. They reside at Drearcliff House, ancestral home of their eldest member. All seems serene and convivial until one by one the members begin to perish in the most grisly of manners. Foul play is suspected by the Good Comrades' insurance agent, who turns to Sherlock Holmes and Dr. John Watson for guidance.
| Actor | Role |
|---|---|
 Basil RathboneSherlock Holmes | Sherlock Holmes |
 Nigel BruceDr. John Watson | Dr. John Watson |
 Aubrey MatherAlastair | Alastair |
 Paul CavanaghSimon Merrivale | Simon Merrivale |
 Dennis HoeyInspector Lestrade | Inspector Lestrade |
 Harry CordingJohn Simpson | John Simpson |
 Holmes HerbertAlan Cosgrave | Alan Cosgrave |
 Sally ShepherdMrs. Monteith | Mrs. Monteith |
 Gavin MuirChalmers | Chalmers |
 Florette HillierAlison MacGregor | Alison MacGregor |
 David ClydeAlex MacGregor | Alex MacGregor |
 Doris LloydBessie | Bessie |
 Cyril DelevantiStanley Raeburn (uncredited) | Stanley Raeburn (uncredited) |
 Alec CraigAngus (uncredited) | Angus (uncredited) |
 Richard AlexanderRalph King (uncredited) | Ralph King (uncredited) |
| BBobby HalePub Patron (uncredited) | Pub Patron (uncredited) |