When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.
| Actor | Role |
|---|---|
 Jeremy BrettSherlock Holmes | Sherlock Holmes |
 Edward HardwickeDr. John Watson | Dr. John Watson |
 Raymond AdamsonSir Charles Baskerville | Sir Charles Baskerville |
 Alastair DuncanDr. Mortimer | Dr. Mortimer |
 Ronald PickupBarrymore | Barrymore |
| RRosemary McHaleMrs. Barrymore | Mrs. Barrymore |
 Kristoffer TaboriSir Henry Baskerville | Sir Henry Baskerville |
 James FaulknerStapleton | Stapleton |
| EEdward RomfourtPurser | Purser |
 Philipp DettmerPageboy | Pageboy |
| SStephen TomlinPerkins | Perkins |
 Fiona GilliesBeryl Stapleton | Beryl Stapleton |
 Bernard HorsfallFrankland | Frankland |
 Don McKillopVicar of Grimpen | Vicar of Grimpen |
| WWilliam IlkleySelden | Selden |
| MMyrtle DevenishPostmistress | Postmistress |
| EElizabeth SpenderLaura Lyons | Laura Lyons |
 Donald BissetManservant (uncredited) | Manservant (uncredited) |