Holmes and Dr. Watson tackle the case of a curse on the Baskerville bloodline in this ABC Movie of the Week adaptation.
| Actor | Role |
|---|---|
 Stewart GrangerSherlock Holmes | Sherlock Holmes |
 Bernard FoxDr. Watson | Dr. Watson |
 William ShatnerGeorge Stapleton | George Stapleton |
 Anthony ZerbeDr. John Mortimer | Dr. John Mortimer |
 Sally Ann HowesLaura Frankland | Laura Frankland |
 Jane MerrowBeryl Stapleton | Beryl Stapleton |
| IIan IrelandSir Henry Baskerville | Sir Henry Baskerville |
 John WilliamsArthur Frankland | Arthur Frankland |
 Alan CaillouInsp. Lestrade | Insp. Lestrade |
 Brendan DillonBarrymore | Barrymore |
| AArline AndersonEliza Barrymore | Eliza Barrymore |
 Liam DunnMessenger | Messenger |
 Michael St. ClairConstable | Constable |
 Barry BernardManager | Manager |
| CConstance CavendishEel Monger | Eel Monger |
| BBilly BowlesBilly Cartwright | Billy Cartwright |
 Arthur MaletHiggins | Higgins |
 Karen KondazianMrs. Mortimer | Mrs. Mortimer |
| EElaine ChurchMaid Servant | Maid Servant |
| JJenifer ShawPeasant Girl | Peasant Girl |
| TTerence PushmanChestnut Vendor | Chestnut Vendor |
| EEric BrothersonPorter | Porter |