 Martin FreemanArthur Dent | Arthur Dent |
 Yasiin BeyFord Prefect | Ford Prefect |
 Zooey DeschanelTrillian | Trillian |
 Sam RockwellZaphod Beeblebrox | Zaphod Beeblebrox |
 Alan RickmanMarvin (voice) | Marvin (voice) |
 Anna ChancellorQuestular Rontok | Questular Rontok |
 Bill NighySlartibartfast | Slartibartfast |
 Richard GriffithsJeltz (voice) | Jeltz (voice) |
 John MalkovichHumma Kavula | Humma Kavula |
 Helen MirrenDeep Thought (voice) | Deep Thought (voice) |
 Thomas LennonEddie the Computer (voice) | Eddie the Computer (voice) |
 Stephen FryNarrator / The Guide (voice) | Narrator / The Guide (voice) |
 Warwick DavisMarvin | Marvin |
 Bill BaileyThe Whale (voice) | The Whale (voice) |
| SSu ElliotPub Customer | Pub Customer |
 Dominique JacksonFook | Fook |
 Simon JonesGhostly Image | Ghostly Image |
 Kelly MacdonaldReporter | Reporter |
 Ian McNeiceKwaltz (voice) | Kwaltz (voice) |
 Steve PembertonMr. Prosser | Mr. Prosser |
 Albie WoodingtonBarman | Barman |
| MMark LonghurstBulldozer Driver | Bulldozer Driver |
| JJack StanleyLunkwill | Lunkwill |
 Mak WilsonVogon Interpreter (voice) | Vogon Interpreter (voice) |
 Mark GatissAdditional Vogon Voices | Additional Vogon Voices |
 Reece ShearsmithAdditional Vogon Voices | Additional Vogon Voices |
| MMason BallCreature Performer | Creature Performer |
| SSarah BennettCreature Performer | Creature Performer |
| DDanny BlacknerCreature Performer | Creature Performer |
 Hayley BurroughsCreature Performer | Creature Performer |
