 Tom PapaEl Superbeasto (voice) | El Superbeasto (voice) |
 Sheri Moon ZombieSuzi X (voice) | Suzi X (voice) |
 Paul GiamattiDr. Satan (voice) | Dr. Satan (voice) |
 Rosario DawsonVelvet Von Black (voice) | Velvet Von Black (voice) |
 Joe AlaskeyErik the Newscaster (voice) | Erik the Newscaster (voice) |
 Ken ForeeLuke St. Luke (voice) | Luke St. Luke (voice) |
 April WinchellDame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice) | Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice) |
 Tom KennyRover / Otto / Old Man / Herbie (voice) | Rover / Otto / Old Man / Herbie (voice) |
 Dee WallaceTrixie (voice) | Trixie (voice) |
 Laraine NewmanLefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice) | Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice) |
 Cassandra PetersonAmber (voice) | Amber (voice) |
 Jess HarnellUncle Carl (voice) | Uncle Carl (voice) |
 Harland WilliamsGerard the Exterminator (voice) | Gerard the Exterminator (voice) |
 Rob PaulsenMichael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice) | Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice) |
 Debra WilsonCigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice) | Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice) |
| TTom KleinMr. Fly (voice) | Mr. Fly (voice) |
 Clint HowardJoe Cthulu (voice) | Joe Cthulu (voice) |
 Brian PosehnMurray (voice) | Murray (voice) |
 Dee Bradley BakerNazi Zombie (voice) | Nazi Zombie (voice) |
 Geoffrey LewisLenny (voice) | Lenny (voice) |
 John DiMaggioBurt the Spurt (voice) | Burt the Spurt (voice) |
 Jeff BennettNerdy Patron (voice) | Nerdy Patron (voice) |
 Danny TrejoRico (voice) | Rico (voice) |
 Carlos AlazraquiBennie Redriguez (voice) | Bennie Redriguez (voice) |
 Tura SatanaVarla (voice) | Varla (voice) |
 Bill MoseleyOtis Driftwood (voice) | Otis Driftwood (voice) |
 Rodger BumpassScreaming Patron (voice) | Screaming Patron (voice) |
 Sid HaigCaptain Spaulding (voice) | Captain Spaulding (voice) |
 Charlie AdlerKrongarr / Mooney McMoon / Albino Singer (voice) | Krongarr / Mooney McMoon / Albino Singer (voice) |
 Kevin Michael RichardsonSanta Baby (voice) | Santa Baby (voice) |
