 Vincent PriceCharles Dexter Ward / Joseph Curwen | Charles Dexter Ward / Joseph Curwen |
 Debra PagetAnn Ward | Ann Ward |
 Lon Chaney Jr.Simon Orne | Simon Orne |
 Frank MaxwellDr. Marinus Willet / Priam Willet | Dr. Marinus Willet / Priam Willet |
 Leo GordonEdgar Weeden / Ezra Weeden | Edgar Weeden / Ezra Weeden |
 Elisha Cook Jr.Gideon Smith / Micah Smith | Gideon Smith / Micah Smith |
 John DierkesBenjamin West / Jacob West | Benjamin West / Jacob West |
 Milton ParsonsJabez Hutchinson | Jabez Hutchinson |
| CCathie MerchantHester Tillinghast | Hester Tillinghast |
 Guy WilkersonGideon Leach / Mr. Leach | Gideon Leach / Mr. Leach |
 Barboura MorrisMrs. Weeden | Mrs. Weeden |
 I. Stanford JolleyCarmody, Coachman | Carmody, Coachman |
 Harry EllerbeMinister | Minister |
| DDarlene LuchtMiss Fitch | Miss Fitch |
 Bruno VeSotaBruno, the Bartender | Bruno, the Bartender |
 Jack TornekLynch Mob Member (uncredited) | Lynch Mob Member (uncredited) |
| NNina BorgetVillager (uncredited) | Villager (uncredited) |
| AAlbert CavensVillager (uncredited) | Villager (uncredited) |
| CCharles FogelVillager (uncredited) | Villager (uncredited) |
