 Jake GyllenhaalJoe Baylor | Joe Baylor |
 Ethan HawkeSgt. Bill Miller (voice) | Sgt. Bill Miller (voice) |
 Riley KeoughEmily Lighton (voice) | Emily Lighton (voice) |
 Peter SarsgaardHenry Fisher (voice) | Henry Fisher (voice) |
 Christina Vidal MitchellSgt. Denise Wade | Sgt. Denise Wade |
 Paul DanoMatthew Fontenot (voice) | Matthew Fontenot (voice) |
 Eli GoreeRick (voice) | Rick (voice) |
 Da'Vine Joy RandolphCHP Dispatcher (voice) | CHP Dispatcher (voice) |
 David CastañedaTim Gerachi | Tim Gerachi |
 Adrian MartinezManny | Manny |
 Christiana MontoyaAbby (voice) | Abby (voice) |
 Gillian ZinserJess Baylor (voice) | Jess Baylor (voice) |
 Aileen BurdockLA Times Operator (voice) | LA Times Operator (voice) |
 Bill BurrNightclub Caller (voice) | Nightclub Caller (voice) |
 Beau KnappDru Nashe (voice) | Dru Nashe (voice) |
 Edi PattersonKatherine Harbor (voice) | Katherine Harbor (voice) |
 Marlene ForteHouse on Fire Caller (voice) | House on Fire Caller (voice) |
 Maurice WebsterGary | Gary |
 Bret Eric PorterMarion | Marion |
 Sal LucioCHP Officer | CHP Officer |
| BBecky WuRiva | Riva |
 Terence J. RotoloCHP Patrolman Rodriguez (voice) | CHP Patrolman Rodriguez (voice) |
 Dillon LaneCrashed Cyclist (voice) | Crashed Cyclist (voice) |
 Oscar BalderramaScott | Scott |
 Jaime FitzSimonsRodriguez's Partner (voice) | Rodriguez's Partner (voice) |
| JJonathan Hunt911 Operator (voice) | 911 Operator (voice) |
