 Benedict CumberbatchThe Grinch (voice) | The Grinch (voice) |
 Rashida JonesDonna Who (voice) | Donna Who (voice) |
 Kenan ThompsonBricklebaum (voice) | Bricklebaum (voice) |
 Cameron SeelyCindy-Lou Who (voice) | Cindy-Lou Who (voice) |
 Angela LansburyMayor McGerkle (voice) | Mayor McGerkle (voice) |
 Pharrell WilliamsNarrator (voice) | Narrator (voice) |
 Ramone HamiltonAxl (voice) | Axl (voice) |
 Sam LavagninoOzzy (voice) | Ozzy (voice) |
 Scarlett EstevezIzzy (voice) | Izzy (voice) |
 Michael BeattieStore Clerk (voice) | Store Clerk (voice) |
 Scott MosierAdditional Voices (voice) | Additional Voices (voice) |
 Lori AlanAdditional Voices (voice) | Additional Voices (voice) |
| CCarter HastingsAdditional Voices (voice) | Additional Voices (voice) |
 Carlos AlazraquiAdditional Voices (voice) | Additional Voices (voice) |
 John KassirAdditional Voices (voice) | Additional Voices (voice) |
 Cathy CavadiniAdditional Voices (voice) | Additional Voices (voice) |
 Danny MannAdditional Voices (voice) | Additional Voices (voice) |
 Meilee CondronAdditional Voices (Voice) | Additional Voices (Voice) |
 Tristan O'HareGroopert (voice) | Groopert (voice) |
 Doug BurchAdditional Voices (voice) | Additional Voices (voice) |
 Tucker ChandlerAdditional Voices (voice) | Additional Voices (voice) |
 Townsend ColemanAdditional Voices (voice) | Additional Voices (voice) |
 Abby CradenAdditional Voices (voice) | Additional Voices (voice) |
 Brian T. DelaneyAdditional Voices (voice) | Additional Voices (voice) |
 John DeMitaAdditional Voices (voice) | Additional Voices (voice) |
 Bill FarmerAdditional Voices (voice) | Additional Voices (voice) |
 Aaron ForsAdditional Voices (voice) | Additional Voices (voice) |
 Willow GeerAdditional Voices (voice) | Additional Voices (voice) |
 Jess HarnellAdditional Voices (voice) | Additional Voices (voice) |
 Evan KishiyamaAdditional Voices (voice) | Additional Voices (voice) |
