Philo Vance investigates when a murderer preys upon members of a wealthy family on New York's Upper East Side.
| Actor | Role |
|---|---|
 William PowellPhilo Vance | Philo Vance |
 Florence EldridgeSibella Greene | Sibella Greene |
 Ullrich HauptDr. Von Blon | Dr. Von Blon |
 Jean ArthurAda Greene | Ada Greene |
 Eugene PalletteSergeant Heath | Sergeant Heath |
 E.H. CalvertJohn F. X. Markham | John F. X. Markham |
 Gertrude NormanMrs. Tobias Greene | Mrs. Tobias Greene |
| LLowell DrewChester Greene | Chester Greene |
 Morgan FarleyRex Greene | Rex Greene |
 Brandon HurstSproot | Sproot |
| AAugusta BurmeisterMrs. Mannheim | Mrs. Mannheim |
 Marcia HarrisHemming | Hemming |
| VVeda BucklandNurse (uncredited) | Nurse (uncredited) |
| SShep CampMedical Examiner (uncredited) | Medical Examiner (uncredited) |
| CCharles E. EvansLawyer Canon (uncredited) | Lawyer Canon (uncredited) |
| HHelena Phillips EvansMiss O'Brien (uncredited) | Miss O'Brien (uncredited) |
| MMildred GoldenBarton (uncredited) | Barton (uncredited) |
 Harry StrangPoliceman (uncredited) | Policeman (uncredited) |