An old trucker steals his truck for one last cross-country run, with a madam and her crew on board.
| Actor | Role |
|---|---|
 Henry FondaElegant John | Elegant John |
 Eileen BrennanPenelope | Penelope |
 Austin PendletonGuido | Guido |
 Robert EnglundBeebo Crozier | Beebo Crozier |
 Dub TaylorHarley Davidson | Harley Davidson |
 John BynerBobby Apples | Bobby Apples |
 Susan SarandonGinny | Ginny |
 Melanie MayronLula | Lula |
| LLeigh FrenchGlinda | Glinda |
 Mews SmallAlice (as Mayra Small) | Alice (as Mayra Small) |
 Daina HouseCeleste (as Dana House) | Celeste (as Dana House) |
 Gary SandyCharlie La Pere | Charlie La Pere |
 Valerie CurtinMary Agnes | Mary Agnes |
| JJohnnie Collins IIIJimmy | Jimmy |
 Bibi OsterwaldAnnie McCarigle | Annie McCarigle |
| BBen FreedmanSammy | Sammy |
 Lyman WardLeland | Leland |
 Tony CacciottiCarl | Carl |
| DDave MorickShiela | Shiela |
| RRick SandackJohn | John |
 Lesley WoodsNurse | Nurse |
 Herb ArmstrongCalvin Engle | Calvin Engle |
 Hank RolikeNighthawk | Nighthawk |
| GGary DowneyOfficer Hogarth | Officer Hogarth |
 Sander VanocurNewscaster | Newscaster |
| HHerman RowlandKelly | Kelly |
| EErnie PaulJimbo | Jimbo |
| SSherri WheatonHighway Patrol Dispatcher | Highway Patrol Dispatcher |
| JJackson BakerCamper | Camper |
 David BondNot listed | Not listed |