It's vacation time for outdoorsy Chicago man Chet Ripley, along with his wife, Connie, and their two kids, Buck and Ben. But a serene weekend of fishing at a Wisconsin lakeside cabin gets crashed by Connie's obnoxious brother-in-law, Roman Craig, his wife, Kate, and the couple's two daughters. As the excursion wears on, the Ripleys find themselves at odds with the stuffy Craig family.
| Actor | Role |
|---|---|
 Dan AykroydRoman Craig | Roman Craig |
 John CandyChet Ripley | Chet Ripley |
 Stephanie FaracyConnie Ripley | Connie Ripley |
 Annette BeningKate Craig | Kate Craig |
 Chris YoungBuck Ripley | Buck Ripley |
 Lucy DeakinsCammie | Cammie |
 Robert ProskyWally | Wally |
 Ian GiattiBen Ripley | Ben Ripley |
 Hilary GordonCara Craig | Cara Craig |
 Rebecca GordonMara Craig | Mara Craig |
 Zoaunne LeRoyJuanita | Juanita |
 Nancy LenehanWaitress | Waitress |
| JJohn BloomJimbo | Jimbo |
 Lewis ArquetteHerm | Herm |
 Britt LeachReg | Reg |
 Cliff BemisBoat Yard Owner | Boat Yard Owner |
| PPaul HansenHot Dog Vendor | Hot Dog Vendor |
| DDebra Lee OrtegaDancing Biker Girl | Dancing Biker Girl |
| SSierra SomervilleGirl in Arcade | Girl in Arcade |
| CChristine SpiottaWoman in Crowd | Woman in Crowd |
| CChris BassLodge Patron | Lodge Patron |
| SShirley HarrisLodge Customer | Lodge Customer |
| CChristopher KinsmanIrate Customer | Irate Customer |
 Andy ProskyGrill Chef | Grill Chef |
 Brian HealyMan in Crowd | Man in Crowd |
 Bart the BearThe Bald-Headed Bear (Jody) | The Bald-Headed Bear (Jody) |
 Raleigh BondGrandpa (uncredited) | Grandpa (uncredited) |