 Clint EastwoodBlondie | Blondie |
 Eli WallachTuco Ramirez | Tuco Ramirez |
 Lee Van CleefSentenza / Angel Eyes | Sentenza / Angel Eyes |
 Aldo GiuffrèAlcoholic Union Captain | Alcoholic Union Captain |
 Luigi PistilliFather Pablo Ramirez | Father Pablo Ramirez |
 Rada RassimovMaria | Maria |
 Enzo PetitoStorekeeper | Storekeeper |
 Claudio ScarchilliTuco Henchman | Tuco Henchman |
 Antonio CasaleBill Carson / Jackson | Bill Carson / Jackson |
 Livio LorenzonBaker | Baker |
 Sandro ScarchilliTuco Henchman | Tuco Henchman |
 Benito StefanelliMember of Angel Eyes' Gang | Member of Angel Eyes' Gang |
| AAngelo NoviMonk | Monk |
 Antonio CasasStevens | Stevens |
 Aldo SambrellMember of Angel Eyes' Gang | Member of Angel Eyes' Gang |
 Al MulockOne-Armed Bounty Hunter | One-Armed Bounty Hunter |
 Sergio MendizábalBlonde Bounty Hunter | Blonde Bounty Hunter |
 Antonio Molino RojoCaptain Harper | Captain Harper |
 Lorenzo RobledoClem | Clem |
 Mario BregaCorporal Wallace | Corporal Wallace |
 Chelo AlonsoStevens' Wife (uncredited) | Stevens' Wife (uncredited) |
 Fortunato Arena1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited) | 1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited) |
 Román AriznavarretaBounty Hunter (uncredited) | Bounty Hunter (uncredited) |
 Silvana BacciMexican Woman with Blondie (uncredited) | Mexican Woman with Blondie (uncredited) |
| JJoseph BradleyOld Soldier (uncredited) | Old Soldier (uncredited) |
 Frank BrañaBounty Hunter #2 (uncredited) | Bounty Hunter #2 (uncredited) |
 Amerigo Castrighella2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited) | 2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited) |
 Saturno CerraBounty Hunter (uncredited) | Bounty Hunter (uncredited) |
| WWilliam ConroyConfederate Soldier (uncredited) | Confederate Soldier (uncredited) |
| AAxel DarnaDying Confederate Soldier (uncredited) | Dying Confederate Soldier (uncredited) |
