Jonathan Drake, while attending his brother's funeral, is shocked to find the head of the deceased is missing. When his brother's skull shows up later in a locked cabinet, Drake realizes an ancient curse placed upon his grandfather by a tribe of South American Jivaro Indians is still in effect and that he himself is the probable next victim.
| Actor | Role |
|---|---|
 Henry DaniellDr. Emil Zurich | Dr. Emil Zurich |
 Valerie FrenchAlison Drake | Alison Drake |
 Grant RichardsLt. Jeff Rowan | Lt. Jeff Rowan |
 Paul WexlerZutai | Zutai |
 Eduard FranzJonathan Drake | Jonathan Drake |
 Frank GerstleDet. Lee Coulter | Det. Lee Coulter |
 Lumsden HareRogers, the butler | Rogers, the butler |
 Howard WendellDr. George Bradford | Dr. George Bradford |
 Paul CavanaghKenneth Drake | Kenneth Drake |
| JJonathan HoleFuneral Director (uncredited) | Funeral Director (uncredited) |
 Arthur ToveyMinister at Funeral (uncredited) | Minister at Funeral (uncredited) |
| BBert StevensMourner at Funeral (uncredited) | Mourner at Funeral (uncredited) |
| HHans MoebusMourner (uncredited) | Mourner (uncredited) |
| AAnthony RedondoAttendant (uncredited) | Attendant (uncredited) |