Tuberculosis is the deadliest killer in human history, responsible for one in four deaths for almost two centuries. While it shaped medical pursuits, social habits, economic development and public policy, TB and its impact are poorly understood.
| Actor | Role |
|---|---|
 Michael MurphyHimself - Narrator (voice) | Himself - Narrator (voice) |
| AAndrea BarrettHerself - Writer | Herself - Writer |
| AAndrea CooperHerself - Immunologist | Herself - Immunologist |
| JJoanne CurtisHerself - TB Survivor | Herself - TB Survivor |
| SSherwood DaviesHimself - TB Survivor | Himself - TB Survivor |
| MMary HotalingHerself - Writer | Herself - Writer |
| PPeter PringleHimself - Writer | Himself - Writer |
| SSheila RothmanHerself - Author, Living in the Shadow of Death | Herself - Author, Living in the Shadow of Death |
| VVivian SchatzHerself - Wife | Herself - Wife |
| WWhitney Seymour Jr.Himself - TB Survivor | Himself - TB Survivor |
| JJohn StoeckleHimself - TB Survivor | Himself - TB Survivor |
| NNancy TomesHerself - Historian | Herself - Historian |