Martin Brundle, born of the human/fly, is adopted by his father's place of employment (Bartok Inc.) while the employees simply wait for his mutant chromosomes to come out of their dormant state.
| Actor | Role |
|---|---|
 Eric StoltzMartin Brundle | Martin Brundle |
 Daphne ZunigaBeth Logan | Beth Logan |
 Lee RichardsonAnton Bartok | Anton Bartok |
 John GetzStathis Borans | Stathis Borans |
 Frank C. TurnerShepard | Shepard |
 Ann Marie LeeDr. Jainway | Dr. Jainway |
 Garry ChalkScorby | Scorby |
 Saffron HendersonRonnie | Ronnie |
 Harley Cross10 year old Martin | 10 year old Martin |
| MMatthew Moore4 year old Martin | 4 year old Martin |
| RRob RoyWiley | Wiley |
| AAndrew RhodesHargis | Hargis |
 Pat BermelMackenzie | Mackenzie |
 William S. TaylorDr. Trimble | Dr. Trimble |
 Jerry WassermanSimms | Simms |
 Robert MetcalfeObserver #1 | Observer #1 |
 Garwin SanfordObserver #2 | Observer #2 |
 Bruce HarwoodTechnician | Technician |
 Lorena GaleWoman | Woman |
 Bill DowMan | Man |
 Duncan FraserObstetrician | Obstetrician |
 Ken Camroux-TaylorLinder | Linder |
 Tom HeatonManager | Manager |
 Allan LysellGuard 'A' | Guard 'A' |
 Suzanne RisticGuard #1 | Guard #1 |
 Danny VirtueGuard #2 | Guard #2 |
 Mike WinlawNeonatologist | Neonatologist |
| KKimelly Anne WarrenMaria | Maria |
| DDavid MylreaFlywalker | Flywalker |
| CCecilia WarrenAnchorwoman | Anchorwoman |