 Pedro PascalReed Richards / Mister Fantastic | Reed Richards / Mister Fantastic |
 Vanessa KirbySue Storm / Invisible Woman | Sue Storm / Invisible Woman |
 Ebon Moss-BachrachBen Grimm / The Thing | Ben Grimm / The Thing |
 Joseph QuinnJohnny Storm / Human Torch | Johnny Storm / Human Torch |
 Ralph InesonGalactus | Galactus |
 Julia GarnerShalla-Bal / Silver Surfer | Shalla-Bal / Silver Surfer |
 Paul Walter HauserHarvey Elder / Mole Man | Harvey Elder / Mole Man |
 Natasha LyonneRachel Rozman | Rachel Rozman |
 Sarah NilesLynne Nichols / F4 Chief of Staff | Lynne Nichols / F4 Chief of Staff |
 Mark GatissTed Gilbert | Ted Gilbert |
| AAda ScottFranklin Richards | Franklin Richards |
 Matthew WoodH.E.R.B.I.E. (voice) | H.E.R.B.I.E. (voice) |
| AAngela JonesMole Man Attack Witness | Mole Man Attack Witness |
| MMaisie ShakmanDonna / Saved Girl | Donna / Saved Girl |
 Jay UnderwoodPower Plant Worker #1 | Power Plant Worker #1 |
 Michael Bailey SmithPower Plant Worker #2 | Power Plant Worker #2 |
 Alex Hyde-WhiteABC Newscaster William Russell | ABC Newscaster William Russell |
 Rebecca StaabChannel 9 Newscaster Carolyn Haynes | Channel 9 Newscaster Carolyn Haynes |
| PPatrick MillerLarry the Lobbyist | Larry the Lobbyist |
 Mather ZickelBoston Newscaster | Boston Newscaster |
 Firdous BamjiYancy Street Man | Yancy Street Man |
 Bertie CaplanWiseass Kid | Wiseass Kid |
| MMax LesterYancy Street Kid | Yancy Street Kid |
| HHunter del Valle MarfoYancy Street Kid | Yancy Street Kid |
| RRiotafari GardnerYancy Street Kid | Yancy Street Kid |
 Isla McRaeYancy Street Kid | Yancy Street Kid |
| MMartin WilkinsonTimely Employee #1 | Timely Employee #1 |
 Greg HaisteTimely Employee #2 | Timely Employee #2 |
 Nathaniel Brimmer-BellerWHIH Reporter Albert Taft | WHIH Reporter Albert Taft |
 Mark WeinmanBaxter Reporter #1 | Baxter Reporter #1 |
