Three lifelong friends travel to Key West, Florida to be bridesmaids in the surprise wedding of their college girlfriend Marilyn. Once there, sisterhoods are rekindled, the past rises up again in all its glory, and there’s enough sparks, drinks, and romance to change all their lives in ways they never expected.
| Actor | Role |
|---|---|
 Susan SarandonLou | Lou |
 Bette MidlerMarilyn | Marilyn |
 Megan MullallyAlice | Alice |
 Sheryl Lee RalphKitty | Kitty |
 Sophie von HaselbergAmanda | Amanda |
 Déjá DeeRhonda Brown | Rhonda Brown |
 Michael BoltonMichael Bolton | Michael Bolton |
 Brandee EvansLeslie | Leslie |
| KKaden TaylorBobby | Bobby |
 Avangeline FriedlanderAimee | Aimee |
 Bruce GreenwoodTed | Ted |
 Renika WilliamsShivani | Shivani |
 Abigail DolanSheila | Sheila |
 David GorenBrandon | Brandon |
 Kadan Well BennettNathan | Nathan |
 Timothy V. MurphyCaptain Ernie | Captain Ernie |
 Molly HargraveYoung Bridal Assistant | Young Bridal Assistant |
 Nicholas VelezJoaquin | Joaquin |
| MMicah EngleBartender | Bartender |
 Lex LaulettaCute Guy | Cute Guy |
| JJohn CrosbyOfficiant | Officiant |
| TThao LeNurse | Nurse |
 Zachary VazquezHandsome Champagne Waiter (uncredited) | Handsome Champagne Waiter (uncredited) |
 Pamela HardyWedding Planner (uncredited) | Wedding Planner (uncredited) |
| MMitchell Patrick GreeneWedding Caterer (uncredited) | Wedding Caterer (uncredited) |
| AArt NewkirkSoiree Attendee (uncredited) | Soiree Attendee (uncredited) |