After the death of Victor Frankenstein, two figures vie for control of his monster and the radical technology that created him: the scientist's daughter, and an immortal wizard assisted by a blind bird-woman with an unquenchable thirst for blood.
| Actor | Role |
|---|---|
 Alberto DalbésDr. Seward | Dr. Seward |
 Dennis PriceDr. Frankenstein | Dr. Frankenstein |
 Howard VernonCagliostro | Cagliostro |
| BBeatriz SavónVera Frankenstein | Vera Frankenstein |
 Carmen YazaldeMadame Orloff | Madame Orloff |
 Anne LibertMelissa | Melissa |
 Fernando BilbaoMonstruo | Monstruo |
 Luis BarbooCaronte | Caronte |
 Daniel WhiteTanner | Tanner |
| DDoris ThomasAbigail | Abigail |
 Jesús FrancoMorpho | Morpho |
 Lina RomayEsmeralda | Esmeralda |
| EEduarda PimentaAsistente de Vera Frankenstein (uncredited) | Asistente de Vera Frankenstein (uncredited) |