The Disappearance of Miss Scott chronicles Hazel Scott’s meteoric rise as a jazz talent and major Hollywood star before being blacklisted during the Red Scare.
| Actor | Role |
|---|---|
 Hazel ScottSelf (archival footage) | Self (archival footage) |
 Sheryl Lee RalphHazel Scott (voice) | Hazel Scott (voice) |
 Alicia KeysSelf | Self |
| AAdam Clayton Powell IIISelf | Self |
| AAshley KahnSelf | Self |
| GGretchen SorinSelf | Self |
| DDwayne MackSelf | Self |
 Michael Eric DysonSelf | Self |
 Karen ChiltonSelf | Self |
| JJason MoranSelf | Self |
| TTammy L. KernodleSelf | Self |
| CCamille ThurmanSelf | Self |
| MMonica O'ConnellSelf | Self |
| LLoren SchoenbergSelf | Self |
 Mickey GuytonSelf | Self |
| MMark CantorSelf | Self |
| MMurray HorwitzSelf | Self |
| MMarcia ChatelainSelf | Self |
 Tracie ThomsSelf | Self |
| FFarah Jasmine GriffinSelf | Self |
 Amanda SealesSelf | Self |
| CCarol StabileSelf | Self |