Minnie Goetze is a 15-year-old aspiring comic-book artist, coming of age in the haze of the 1970s in San Francisco. Insatiably curious about the world around her, Minnie is a pretty typical teenage girl. Oh, except that she’s sleeping with her mother’s boyfriend.
| Actor | Role |
|---|---|
 Bel PowleyMinnie Goetze | Minnie Goetze |
 Kristen WiigCharlotte Worthington | Charlotte Worthington |
 Alexander SkarsgårdMonroe Rutherford | Monroe Rutherford |
 Christopher MeloniPascal MacCorkill | Pascal MacCorkill |
 Austin LyonRicky Wasserman | Ricky Wasserman |
 Madeleine WatersKimmie Minter | Kimmie Minter |
 Margarita LevievaTabatha | Tabatha |
| QQuinn NagleChuck Saunders | Chuck Saunders |
| AAbby WaitGretel | Gretel |
| JJohn ParsonsBurt | Burt |
 Miranda BaileyAndrea | Andrea |
| CCarson D. MellMichael Cocaine | Michael Cocaine |
| DDavy ClementsArnie | Arnie |
 Susannah RogersAline Kominsky (voice) | Aline Kominsky (voice) |
| AAnthony WilliamsFrankie | Frankie |
| CCharles Lewis IIICool English Teacher | Cool English Teacher |
 David FineOld Hippie | Old Hippie |
 Joshua GrannellDrag Queen | Drag Queen |
| NNate HellerBand Member | Band Member |
| LLance HillBand Member | Band Member |
| JJon FreemanBand Member | Band Member |
| PPersephone Gloeckner-SuitsStudent | Student |