The Defenders are a crack team of lawyers dedicated to one principle - the accused is innocent untill proven guilty. This time, they defend a man wrongly convicted of murder.
| Actor | Role |
|---|---|
 Beau BridgesDon Preston | Don Preston |
 E.G. MarshallLawrence Preston | Lawrence Preston |
 Martha PlimptonMary Jane Preston | Mary Jane Preston |
 Jon PolitoD.A. Al Orsini | D.A. Al Orsini |
 LisaGay HamiltonJeanne Baptiste | Jeanne Baptiste |
 Mimi KuzykCamille Preston | Camille Preston |
 James McDanielJack Casey | Jack Casey |
 David HemblenNot listed | Not listed |
 Melanie Nicholls-KingSarah Casey | Sarah Casey |
 Christopher RedmanNot listed | Not listed |
| CChristopher RedmondSteven Preston | Steven Preston |
 Oliver BeckerBrian Clarke | Brian Clarke |
 Marium CarvellSally McAstin | Sally McAstin |
 Nancy PalkJudge Karnes | Judge Karnes |
 Michael CopemanJudge Minton | Judge Minton |
 Falconer AbrahamLouis Baptiste | Louis Baptiste |
 A.C. PetersonVinnie Keefe | Vinnie Keefe |
 Scott WickwareSergeant Dave Wilson | Sergeant Dave Wilson |
| RRoss PettyDoctor Nagel | Doctor Nagel |
 Cameron MathisonMike Murphy | Mike Murphy |
| PPatricia WelbourneYoung Hooker | Young Hooker |
| JJunior WilliamsCorrections Officer #1 | Corrections Officer #1 |