Trapped between the living and the dead, Diego de la Muerte fights to rescue his soul from the evil god of death that controls him. But a bigger battle awaits him when the Aztec god demands the soul of Maria, the girlfriend Diego left behind.
| Actor | Role |
|---|---|
 Wilmer ValderramaDiego de la Muerte | Diego de la Muerte |
 Angie CepedaMaria | Maria |
 Joel David MooreZak | Zak |
 Michael ParksSheriff Ezra Stone | Sheriff Ezra Stone |
 Tony PlanaAparicio | Aparicio |
 E.J. CallahanThe Monsignor | The Monsignor |
 Tony AmendolaPadre Somera | Padre Somera |
 Alfonso ArauTezcatlipoca (voice) | Tezcatlipoca (voice) |
 Billy DragoThe Old Indian | The Old Indian |
 María Conchita AlonsoThe Nun | The Nun |
| DDarien DikeosYoung Diego | Young Diego |
 Aldo GonzalezCameo | Cameo |
 D. Taylor LoebCelia | Celia |
 Vince LozanoCoyote | Coyote |
| MMichael MacoulRemy | Remy |