This animated series is based on the graphic novels by Brian Wood. The Cramp Twins follows the adventures of 10-year-old twins Lucien and Wayne Cramp--total opposites who constantly drive each other crazy, waging an endless, highly entertaining slapstick cartoon war.
| Actor | Role |
|---|---|
 Tom KennyWayne Cramp (voice) | Wayne Cramp (voice) |
 Kath SoucieLucien Cramp (voice) | Lucien Cramp (voice) |
 Ian James CorlettMr. Cramp (voice) | Mr. Cramp (voice) |
 Nicole OliverMrs. Cramp (voice) | Mrs. Cramp (voice) |
 Tabitha St. GermainMari Phelps (voice) | Mari Phelps (voice) |
| TTerry KlassenTony Parsons / Mr. Parsons (voice) | Tony Parsons / Mr. Parsons (voice) |
| JJayne PatersonWendy Winkle (voice) | Wendy Winkle (voice) |
 Colin MurdockMr. Winkle (voice) | Mr. Winkle (voice) |
 Cathy WeseluckMiss Hissy (voice) | Miss Hissy (voice) |
 Lee TockarDirty Joe (voice) | Dirty Joe (voice) |